任深圳

职称: 讲师、硕士生导师

教育背景:

2015-2020，南京大学，生命科学学院，博士；

2011-2015，江苏大学，药学院，本科；

工作履历:

2020-至今：河北工业大学，讲师、硕导

研究领域与承担项目:

研究领域：

1） 多功能纳米载体在肿瘤多模态成像、光学治疗、免疫治疗及联合治疗等方面的应用；

2） 靶向小分子抑制剂的设计、合成及生物活性研究

承担项目：

1） 河北省高等学校科学技术研究项目重点项目，2021-2023，10万，主持；

2） 国家自然科学基金面上项目，21877060，2019-2022，67.5万元，参与；

3） 国家自然科学基金面上项目，81671390，2017-2020，60万元，参与。

学术成果: 

代表论文（*为通讯作者，#为共同第一作者）：

[1] Ren SZ;  Zhu XH;  Wang B; Liu M; Li SK; Yang YS*; An HL*; Zhu HL*, A Versatile Nanoplatform based on Multivariate Porphyrinic Metal-Organic Frameworks for Catalytic Cascade-Enhanced Photodynamic Therapy, Journal of Materials Chemistry B, 2021, DOI: 10.1039/d0tb02652b

[2] Ren SZ; Wang B;  Zhu XH; Zhu D;Liu M;  Li SK;  Yang YS*; Wang ZC*; Zhu HL*, Oxygen Self-Sufficient Core-Shell Metal-Organic Framework-based Smart Nanoplatform for Enhanced Synergistic Chemotherapy and Photodynamic Therapy, ACS Applied Materials & Interfaces, 2020, 12(22): 24662-24674.

[3] Ren SZ; Zhu D; Zhu XH; Wang B;  Yang YS;  Sun WX; Wang XM;  Lv PC*; Wang ZC*; Zhu HL*, Nanoscale Metal-Organic Frameworks Coated by Biodegradable Organosilica for pH and Redox Dual Responsive Drug Release and High-Performance Anticancer Therapy, ACS Applied Materials & Interfaces, 2019, 11(23): 20678-20688.

[4] Ren SZ#; Wang ZC#*; Zhu D; Zhu XH; Shen FQ; Wu YS;  Chen JJ;  Xu C*;  Zhu HL*, Design, Synthesis and Biological Evaluation of Novel Ferrocene-Pyrazole Derivatives Containing Nitric Oxide Donors as COX-2 Inhibitors for Cancer Therapy, European Journal of Medicinal Chemistry, 2018, 157: 909-924.

[5] Ren SZ#; Ren SZ#*;  Zhu XH; Zhu D; Zhang L;  Shen FQ; Duan YT; Cao H; Zhao J*;  Zhu HL*, Design and Biological Evaluation of Novel Hybrids of 1, 5-Diarylpyrazole and Chrysin for Selective COX-2 Inhibition, Bioorganic & Medicinal Chemistry, 2018, 26(14): 4264-4275.

[6]Sun J#; Ren SZ#;  Lu XY;  Li JJ; Shen FQ; Xu C*;  Zhu HL*, Discovery of A Series of 1, 3, 4-Oxadiazole-2 (3H)-thione Derivatives Containing Piperazine Skeleton as Potential FAK Inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25(9): 2593-2600.

[7]  Zhu XH;Du JX; Zhu D; Ren SZ*;  Chen K*; Zhu HL*, Recent Research on Methods to Improve Tumor Hypoxia Environment, Oxidative Medicine and Cellular Longevity, 2020, 5721258.

[8]Zhu D; Zhu XH; Ren SZ; Lu YD*;  Zhu HL*, Manganese Dioxide (MnO2) Based Nanomaterials for Cancer Therapies and Theranostics, Journal of Drug Targeting, 2020, DOI: 10.1080/1061186X.2020.1815209

[9] Liu Q; Shi WK; Ren SZ;  N WW;  Li WY.;  Chen HM; Liu P; Yuan J;  He XS;  Liu JJ; Cao P; Yang PZ;  Xiao ZP*;  Zhu HL*, Arylamino Containing Hydroxamic Acids as Potent Urease Inhibitors for the Treatment of Helicobacter Pylori Infection, European Journal of Medicinal Chemistry, 2018, 156: 126-136.

[10] Ni WW;  Liu Q; Ren SZ;  Li WY; Yi LL; Jing H; Sheng LX; Wan Q;  Zhong PF; Fang HL; Hui OY;  Xiao ZP*; Zhu HL*, The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections, Bioorganic & Medicinal Chemistry, 2018, 26(14): 4145-4152.

发明专利：

[1] 朱海亮、任深圳、朱丹、王忠长、徐琛：一类含NO供体的二茂铁-吡唑磺胺衍生物的设计、合成及其生物活性评价。申请号：CN201810766827.1，公开号：CN110698519A.

[2] 朱海亮、任深圳、朱晓华、王忠长、赵劲：一类含吡唑骨架的白杨素衍生物的设计、合成及其生物活性评价，申请号：CN201810766829.0，公开号：CN110698464A.