徐炳祥
职称： 副教授
教育背景：
2007/09-2011/07、东北师范大学、数学与应用数学/计算机软件、双学士
2011/09-2014/06、中南大学、概率论与数理统计、硕士
2016/09-2020/07、中国科学院大学、生物信息学、博士
工作履历：
2014/07-2016/08、中国科学院北京基因组研究所、研究实习员
2020/07-2021/02、江苏先声医学诊断有限公司、生物信息工程师
2021/03-2024/07、上海体育大学运动健康学院、教师
2024/08-今、河北工业大学生命科学与健康工程学院、教师
学术兼职：
中国生物物理学会运动与公共健康分会、青年理事
研究领域与承担项目
研究领域：
表观基因组学、生物信息学、分子流行病学
承担项目：
2023.1-2025.12、主持、染色质构象捕获数据的测序深度不敏感表示及其应用研究、国家自然科学基金青年科学基金项目
2019.1-2022.12、参与、基于ATAC-seq高精度预测染色质相互作用的新方法和基于增强现实的3D基因组数据可视化、国家自然科学基金项目
2018.1-2018.12、参与、基于结构信息论的高精度染色体结构域识别方法、国家自然科学基金应急管理项目
2016.1-2018.12、参与、细胞分化过程中长非编码RNA介导的三维基因组遗传信息传递网络的解析、国家自然科学基金重大研究计划项目
学术成果：
学术论文：
第一/通信作者：
1）Bingxiang Xu 1, #, Xiaomeng Gao 1, Xiaoli Li, Feifei Li #, Zhihua Zhang #. (2024). Crosslinking intensity modulates the reliability and sensitivity of chromatin conformation detection at different structural levels. Communications Biology, 2024, 7(1): 1216.
2）Lei Sun 1, Jinwen Luan 1, Jinbiao Wang 1, Xiaoli Li, Wenqian Zhang, Xiaohui Ji, Longhua Liu #, Ru Wang #, Bingxiang Xu #. (2024). GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses. Journal of Sport and Health Science, 2024: 100992.
3）Bingxiang Xu 1, #, Xiaomeng Gao 1, Xiaoli Li, Yan Jia, Feifei Li #, Zhihua Zhang #. (2022). Cell cycle arrest explains the observed bulk 3D genomic alterations in response to long-term heat shock in K562 cells. Genome research 32, 1285-1297.
4）Bingxiang Xu 1, #, Xiaoli Li, Xiaomeng Gao, Yan Jia, Jing Liu, Feifei Li #, Zhihua Zhang #. (2022). DeNOPA: decoding nucleosome positions sensitively with sparse ATAC-seq data. Briefings in bioinformatics 23, bbab469.
5）Bingxiang Xu 1, #, Mingjie Lu 1, Linlin Yan 1, Minghui Ge, Yong Ren, Ru Wang #, Yongqian Shu #, Lin Hou #, Hao Guo #. (2021). A Pan-Cancer Analysis of Predictive Methylation Signatures of Response to Cancer Immunotherapy. Frontiers in immunology 12, 796647.
6）Binxin Xu 1, Jiahui Chen 1, Shaohua Zhang 1, Shengli Shen, Xuan Lan, Zhineng Chen, Zhiqiang Yan, Bingxiang Xu #. (2021). Association Between the Severity of Diabetic Retinopathy and Optical Coherence Tomography Angiography Metrics. Frontiers in endocrinology 12, 777552.
7）Bingxiang Xu 1, Hao Ge, Zhihua Zhang #. (2017). An efficient and assumption-free method to approximate protein level distribution in the two-states gene expression model. Journal of theoretical biology 433, 1-7.
综述：
1）Xingsheng Jin 1, Yang Chen 1, Bingxiang Xu #, Haili Tian #. (2024). Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions. Biology, 2024, 13(4): 247.
2）Bingxiang Xu 1, Zhihua Zhang #. (2016). Computational inference of physical spatia organization of eukaryotic genomes. Quantitative Biology 4, 8.
其他：
1）Feifei Li 1, Danyang Wang 1, Ruigao Song 1, Chunwei Cao 1, Zhihua Zhang 1,#, Yu Wang, Xiaoli Li, Jiaojiao Huang, Qiang Liu, Naipeng Hou, Bingxiang Xu, Xiao Li, Xiaomeng Gao, Yan Jia, Jianguo Zhao, Yanfang Wang # (2020). The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos. Genome biology 21, 203.
2）Angsheng Li 1,#, Xianchen Yin 1, Bingxiang Xu, Danyang Wang, Jimin Han, Yi Wei, Yun Deng, Ying Xiong, Zhihua Zhang # (2018). Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy. Nature communications 9, 3265.
1）Hui Zhang 1, Feifei Li 1, Yan Jia, Bingxiang Xu, Yiqun Zhang, Xiaoli Li, Zhihua Zhang #. (2017). Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution. Nucleic acids research 45, 12739-12751.
专利：
郭昊, 徐炳祥, 葛明晖, 颜林林, 李诗濛, 任用. 基于DNA甲基化谱的肿瘤免疫检查点抑制剂治疗有效性评估模型的构建方法[P]. 江苏省：CN112735513B,2021-11-19.
