赵震

赵震

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职称: 副教授、硕士生导师

教育背景:

2013-2018 美国密苏里大学药学院,博士

2007-2011 中国药科大学药学院,学士

工作履历:

2021-至今 河北工业大学 讲师、副教授,硕士生导师

2018-2020 美国密苏里大学药学院 博士后研究员

研究领域与承担项目:

研究领域:

1)核酸类药物开发及其递送系统的构建研究

2)多肽、蛋白类药物开发用于精准纳米医学研究

3)蛋白靶向降解药物的开发研究

基金和项目:

1) 河北省精准医学创新发展联合基金培育项目,2025-2027,主持

2) 天津市技术创新引导专项(基金)项目,2025-2027,主持

3) 河北省高等学校科学研究项目(产学研专项),2025-2027,主持

4) 石家庄市科技合作专项重大项目,2025-2026,主持

5) 天津市应用基础研究项目青年项目,2023-2025,主持

6) 石家庄市科技合作专项一般项目,2023-2024,主持

7) 国家自然科学基金青年项目(C类),2022-2024,主持

8) 河北省引进留学人员资助项目,2022-2025,主持

9) 河北省自然科学基金绿色通道项目,2021-2023,主持

奖励与荣誉:

2017年美国药学学会(AAPS)生物技术类研究生最佳科研奖

2024年河北省科学技术厅,河北省场景创新大赛(先进算力领域),三等奖

学术成果:

代表性论文:

(1)Zhen Zhao, John Fetse, Umar-Farouk Mamani, Yuhan Guo, Yuanke Li, Pratikkumar Patel, Yanli Liu, Chien-Yu Lin, Yongren Li, Bahaa Mustafa, Kun Cheng*. Development of a peptide-based tumor-activated checkpoint inhibitor for cancer immunotherapy. Acta Biomaterialia.2025,193:484-497

(2) Yuanke Li, Ruiying Liu, Zhen Zhao*. Targeting Brain Drug Delivery with Macromolecules Through Receptor-Mediated Transcytosis. Pharmaceutics.2025, 17(1):109

(3) Biao Ma, Sai Shi, Wei Guo, Hailin Zhang, Zhen Zhao*, Hailong An*. Liensinine, a Novel and Food-Derived Compound, Exerts Potent Antihepatoma Efficacy via Inhibiting the Kv10.1 Channel. Journal of Agricultural and Food Chemistry.2024,72,9,4689-4702

(4) Biao Ma, Sai Shi, Shuxi Ren, Chang Qu, Zhen Zhao*, Hailong An*. Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability. European Journal of Pharmacology.2024,962,176240

(5) Yuanke Li#; Zhen Zhao#; Chien-Yu Lin; Yanli Liu; Kevin F. Staveley-O Carroll; Guangfu Li; Kun Cheng*; Silencing PCBP2 Normalizes Desmoplastic Stroma and Improves the Antitumor Activity of Chemotherapy in Pancreatic Cancer, Theranostics, 2021, 11(5): 2182-2200.

(6) Zhen Zhao#; Yuanke Li#; Hao Liu; Akshay Jain; Pratikkumar Vinodchandra Patel; Kun Cheng*; Co-delivery of IKBKE siRNA and Cabazitaxel by Hybrid Nanocomplex Inhibits Invasiveness and Growth of Triple-Negative Breast Cancer, Science Advances, 2020, 6(29): eabb0616

(7) Zhen Zhao; Yuanke Li; Ravi Shukla; Hao Liu; Akshay Jain; Ashutosh Barve; Kun Cheng*; Development of a Biocompatible Copolymer Nanocomplex to Deliver VEGF siRNA for Triple Negative Breast Cancer, Theranostics, 2019, 9(15): 4508-4524

(8) Zhen Zhao, Chien-Yu Lin, Kun Cheng*. siRNA- and miRNA-Based Therapeutics for Liver Fibrosis. Translational Research. 2019 (214), p. 17-29

(9) Zhen Zhao; Yuanke Li; Akshay Jain; Zhijin Chen; Hao Liu; Wei Jin; Kun Cheng*; Development of a Peptide-Modified siRNA Nanocomplex for Hepatic Stellate Cells, Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 14(1): 51-61