张然
职称: 讲师、硕士生导师
教育背景:
2017-2020 南开大学生科院 博士
2014-2016 中科院过程所 联合培养硕士
2013-2016 河北大学化学学院 硕士
2009-2013 河北科技大学化工学院 学士
工作履历:
2020-至今 河北工业大学
学术兼职:
天津市救援医学学会烧伤与创面修复分会委员
研究领域与承担项目:
研究领域:
1)干细胞联合微纳米材料促进组织再生的研究;
2)近红外响应纳米材料治疗缺血性疾病的研究
承担项目:
1)河北省高等学校科学研究项目重点项目,“干细胞机器人”的构建及其对心肌梗死治疗的机制研究,2021-2023,主持;
2)开放课题,“仿生纳米药物”对心肌缺血再灌注损伤炎症微环境调控作用的研究,2021-2022,主持;
3)开放课题,基因工程化的间充质干细胞衍生纳米颗粒治疗心肌缺血,2022-2024,主持。
奖励与荣誉:
河北工业大学“元光学者”
学术成果:
[1] Zhang Xiangyun, Zhang Yue, Zhang Ran, Jiang Xinbang, Adam C Midgley, Liu Qiqi, Kang Helong, Wu Jin, Anila Khalique, Qian Meng, An Di, Huang Jing, Ou Lailiang, Zhao Qiang, Zhuang Jie, Yan Xiyun, Kong Deling, Huang Xinglu*. Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues, Advanced Materials, 2022, 34(14):2110352.
[2] Geng Hao, Pan Yuchen, Zhang Ran, Gao Dong, Wang Zijuan, Li Boying, Li Ning, Guo Dongsheng*, Xing Chengfen*. Binding to Amyloid-β Protein by Photothermal Blood-Brain Barrier-Penetrating Nanoparticles for Inhibition and Disaggregation of Fibrillation, Advanced Functional Materials, 2021, 31(41): 2102953.
[3] Zhang Ran, Luo Wenya, Zhang Yue, Zhu Dashuai, Adam Midgley, Song Hao, Anila Khalique, Zhang Haoqi, Zhuang Jie, Kong Deling*, Huang Xinglu*. Particle-Based Artificial Three-Dimensional Stem Cell Spheroids for Revascularization of Ischemic Diseases, Science Advances, 2020, 6(19): eaaz8011.
[4].Zhang R, Li Y, Hu BB, et al. Traceable Nanoparticles Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cells Differentiation for Alzheimer's Disease Therapy. [J]. Advanced Materials, 2016, 28, 6345–6352.
[5]. 张然,罗文亚,朱明盛等。纳米活性材料在间充质干细胞治疗中的应用[J]. 中国材料进展,2019(06): 542-550。
[6]. Ma LL, Ge K, Zhang R, et al. Synthesis, characterization, cytotoxicity of mixed ligand complexes of palladium(II) with dipyrido[3,2-d:2',3'-f] quinoxaline/dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine and 4-toluensulfonyl-L-amino acid dianion.[J]. European Journal of Medicinal Chemistry, 2014, 87:624-630.
[7]. Zhang Y, Du M, Zhang R, Shang ZH and Yu YF. Research on Synthesis of Resveratrol with Microwave Irradiation. E. Purshotaman, cds. International Conference on Biological, Medical and Chemical Engineering (BMCE 2013).
代表性专利:
1)邢成芬,张然,高冬,邱亮,王紫娟。一种透明质酸复合微针贴片的制备和应用。专利申请号:202211372841.6.