张廷斌

职称: 讲师、硕士生导师

教育背景:

2012-2018天津大学化工学院，硕博连读

2014-2018 国家纳米科学中心，联合培养

2008-2012合肥工业大学化工学院，学士

工作履历:

2022-今 河北工业大学生命科学与健康工程学院，讲师

2018-2022西北大学化学学科，博士后

学术兼职：

生物医学工程学会会员

研究领域与承担项目:

研究领域：

生物医用纳米材料；多功能水凝胶；药物/基因递送

基金和项目：

1. 国家自然科学基金（青年），新型高效siRNA纳米载体的构建及其蛋白冠在体磁热调控与转染增效机制研究，2021-2023，主持。

2. 十四五国家重点研发计划项目，高活性仿生骨材料诱导颅骨再生修复的机制研究，2024-2027，骨干成员。

3. 中国博士后科学基金面上资助一等资助，新型CRISPR/Cas9载体的构建及其肝癌靶向治疗研究，2019-2020，主持。

4. 陕西省自然科学基金（青年），伪装涡旋磁纳米环基因载体的构建及其磁热/基因联合治疗肝癌研究，2020-2021，主持。

5. 国家自然科学基金面上项目，新型磁热RNA药物递送系统构建及其免疫激活效应研究，2022-2025，参加。

6. 陕西省科技创新团队, 生物医用磁学纳米材料创新团队, 2021—2024，核心成员

奖励与荣誉:

天津大学“优博”基金获得者

河北工业大学“元光学者”

学术成果:

代表性论文（#为共同一作，*为通讯作者）：

1. T. Zhang#, G. Li#, Y. Miao, J. Lu, N. Gong, Y. Zhang, Y. Sun, Y. He, M. Peng, X. Liu, X.-J. Liang, H. Fan*, Magnetothermal regulation of in vivo protein corona formation on magnetic nanoparticles for improved cancer nanotherapy. Biomaterials, 2021, 276, 121021, IF: 12.479.

2. T. Zhang#, Y. Huang#, X. Ma#, N. Gong, X. Liu, L. Liu, X. Ye, B. Hu, C. Li, J.-H. Tian, A. Magrini, J. Zhang, W. Guo*, J.-F. Xing*, M. Bottini, X.-J. Liang*, Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape. Nano Letters, 2018, 18, 6301, IF: 11.189.

3. T. Zhang#, W. Guo#, C. Zhang, J. Yu, J. Xu, S. Li, J.-H. Tian, P.C. Wang, J.-F. Xing*, X.-J. Liang*, Transferrin-Dressed Virus-like Ternary Nanoparticles with Aggregation-Induced Emission for Targeted Delivery and Rapid Cytosolic Release of siRNA. ACS Applied Materials & Interfaces, 2017, 9, 16006, IF: 9.229.

4. J. Lu, X. Gao, S. Wang, Y. He, X. Ma, T. Zhang*, and Xiaoli Liu*, Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials. Exploration 2023, 3, 20220045.

5. J. Li, J. Yuan, H. Li, J. Guo, M. Li, T. Zhang*, X.-J. Liang, H. Fan, X. Liu*; Advances in Nanocarriers for Delivering Therapeutic Agents against Hepatitis B Virus, Advanced NanoBiomed Research, 2024, DOI: 10.1002/anbr.202300132.

6. Y. Wang#, T. Zhang#, X.-J. Liang *, Aggregation-Induced Emission: Lighting up Cells, Revealing Life! Small, 2016, 12, 6451, IF: 13.281. (封面文章)

7. T. Zhang#, X. Song#, D. Kang, L. Zhang, C. Zhang, S. Jin, C. Wang, J. Tian, J. Xing*, X.-J. Liang*, Modified bovine serum albumin as an effective charge-reversal platform for simultaneously improving the transfection efficiency and biocompatibility of polyplexes. Journal of Materials Chemistry B, 2015, 3, 4698, IF: 6.331.

8. C. Zhang#, T. Zhang#, S. Jin, X. Xue, X. Yang, N. Gong, J. Zhang, P.C. Wang, J.-H. Tian, J. Xing*, X.-J. Liang*, Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery. ACS Applied Materials & Interfaces 2017, 9, 4425, IF: 9.229.

9. T. Zhang, Q. Zhang, J.-H. Tian, J.-F. Xing*, W. Guo*, X.-J. Liang*, Perfluorocarbon-based nanomedicine: emerging strategy for diagnosis and treatment of diseases. MRS Communications 2018, 8, 303, IF: 2.566.

10. H. Gao#, T. Zhang#, Y. Zhang, Y.M. Chen, B. Liu, J. Wu, X.L. Liu, Y. Li, M. Peng, Y. Zhang, G. Xie, F. Zhao, H. Fan*, Ellipsoidal Magnetite Nanoparticles: A New Member of Magnetic-Vortex Nanoparticles Family for Efficient Magnetic Hyperthermia. Journal of Materials Chemistry B, 2020, 8, 515, IF: 6.331.

11. X. Zheng#, T. Zhang#, X. Song, L. Zhang, C. Zhang, S. Jin, J. Xing*, X.-J. Liang*, Structural impact of graft and block copolymers based on poly(N-vinylpyrrolidone) and poly(2-dimethylaminoethyl methacrylate) in gene delivery. Journal of Materials Chemistry B 2015, 3, 4027, IF: 6.331.

12. Y. Song#, T. Zhang#, X. Song, L. Zhang, C. Zhang, J. Xing*, X.-J. Liang*, Polycations with excellent gene transfection ability based on PVP-g-PDMAEMA with random coil and micelle structures as non-viral gene vectors. Journal of Materials Chemistry B 2015, 3, 911, IF: 6.331.

13. 张廷斌, 卢俊杰, 邱滢, 张欢, 刘晓丽, 彭明丽, 樊海明*,超顺磁氧化铁纳米颗粒的可控制备及其磁感应热性能分析——介绍一个大学化学综合实验. 大学化学, 2022, 37, 2112058.

代表性专著及专利：

1. T. Zhang, C. Zhang, J. Xing, J. Xu, C. Li, P.C. Wang, X.-J. Liang*, Multifunctional Dendrimers for Drug Nanocarriers. Novel Approaches for Drug Delivery 2016, 245-276.

2.梁兴杰; 张廷斌; 郭伟圣; 一种核酸递送载体及其制备方法和应用, 2017-9-28,中国, ZL201710896244.6.